By 1925, the Amahuaca still rejected contact with whites and the indigenous groups mentioned above. They only maintained peaceful relations with the Aashinahua and the Campa Asháninka. By 1962, some families of this group decided to leave the headwaters of the Curiuja tributaries and settle on the banks of the Urubamba River.
With a census population of 247 people, the Amahuaca represent only 0.10% of the census indigenous population.
The Amahuaca suffered considerable demographic devastation during the so-called rubber boom, when severe epidemics significantly reduced their population.